Automated Morphologic Differentiation Between Iron Deficiency Anemia and Thalassemia.

ABSTRACT:

Background

Iron deficiency anemia (IDA) and hemoglobinopathies (HbP) are two frequent conditions characterized by microcytemia. Published criteria/scores discriminating these conditions with hematology analyzer parameters are not fully satisfactory. Although patients with HbP have been reported to have more red blood cells (RBC) with a target cell (TC) morphology than patients with IDA, obtaining TC percentages remains a time-consuming task since at least 1000 RBC must be examined.

Methods

Using the Mindray CAL 8000 2.0 0111 and MC-80 module, 152 microcytic samples from 51 patients with IDA and 101 with HbP were analyzed. Data from RBC parameters used in published scores were collected, as well as the percentages of target cells automatically provided by the MC-80.

Result

SUBMITTER: Guy J 

PROVIDER: S-EPMC12514970 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature