Abnormal maximal tubular reabsorption of phosphate as a novel biomarker of physical dysfunction in older adults.

ABSTRACT:

Background

Physical dysfunction is a preclinical stage of disability in older adults, linked to severe adverse outcomes such as death and hospitalization. Maximal tubular reabsorption of phosphate (TmP/GFR), as a key biomarker of phosphate metabolism, may be related to physical dysfunction, but this relationship has not yet been explored.

Methods

Using data from the Rugao Longitudinal Ageing Study (RLAS), longitudinal logistic regression was employed to explore the relationship between abnormal TmP/GFR and physical dysfunction. For validation, the UK Biobank dataset was combined, and mendelian randomization (MR) was conducted to investigate causality. The maximal phosphate reabsorption was assessed using TmP/GFR, while physical dysfunction were evaluated through grip strengt

SUBMITTER: Sun M 

PROVIDER: S-EPMC12515114 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature