Temporal and protein-specific S-palmitoylation supports synaptic and neural network plasticity.

ABSTRACT:

Background

Synaptic plasticity, a fundamental process underlying learning and memory, depends on activity-driven changes in neural connectivity. S-palmitoylation, a reversible post-translational lipid modification, modulates synaptic protein function by influencing protein conformation, localization, trafficking, and molecular interactions. Despite its known significance in neuronal function, the temporal and protein-specific dynamics of S-palmitoylation during synaptic plasticity remain poorly understood.

Methodology & principal findings

Using electrophysiological methods, molecular biology, proteomics, and imaging across various models (neuronal cultures, hippocampal slices, and synaptoneurosomes), we investigated S-palmitoylation during synaptic activity. Induction of lon

SUBMITTER: Pytys A 

PROVIDER: S-EPMC12515174 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature