Molecular characterization and clinical features of diffuse midline glioma in the pediatric precision oncology registry INFORM.

ABSTRACT: Diffuse midline glioma (DMG; a subtype of pediatric high-grade glioma) is a fatal disease in children, due to the localization in critical structures of the central nervous system, its invasive nature, and limited treatment options. Molecularly, DMG with loss of histone 3 K27 trimethylation (mostly through the typical K27M-mutation in histone 3) have been relatively well characterized, however, no unambiguous Achilles' heel for targeted therapeutic approaches could be identified to date. This study integrates detailed molecular characteristics of pediatric DMGs with clinical data in a large, international cohort in order to contribute to a better understanding necessary for further development of therapeutic approaches. A total of 162 DMG tumors were analyzed within the INFORM registry fro

SUBMITTER: Pfaff E 

PROVIDER: S-EPMC12515216 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature