The role of RANBP1 in regulating MiRNA expression and apoptosis in breast cancer cells.

ABSTRACT:

Background

Breast cancer poses a huge health threat in China. Emerging evidence has indicated that RANBP1 is associated with poor prognosis of breast cancer and has been shown to influence miRNA expression in colorectal cancer. But its role in breast cancer remains unclear.

Objective

The purpose of this research is to construct the sh-RANBP1 cell line derived from a human breast cancer cell line in order to investigate the impact of low RANBP1 expression on the expression network of breast cancer-associated miRNAs and mRNAs.

Methods

We constructed the sh-RANBP1 cell line from the human breast cancer cell line MDA-MB-231 and analyzed the significant differential expression between the two groups using miRNA sequencing and mRNA sequencing of both the sh-RANBP1 group and

SUBMITTER: Song P 

PROVIDER: S-EPMC12515217 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature