International Trends in Opioid Prescribing by Age and Sex from 2001 to 2019: An Observational Study Using Population-Based Databases from 18 Countries and One Special Administrative Region.

ABSTRACT:

Objective

To characterize multinational trends and patterns of opioid analgesic prescribing by sex and age.

Design, setting, and participants

We studied opioid analgesic prescribing from 2001 to 2019 with common protocol using population-based databases from eighteen countries and one special administrative region.

Main outcome measures

We measured opioid prescribing by geographical region, sex and age, estimating annual prevalent, incident, and nonincident opioid prescribing per 100 population with a 95% confidence interval (CI) and meta-analyzed the multinational and regional opioid prescribing with a random-effects model. Time trends were reported through average annual absolute changes, estimated using linear mixed models. We further explored the effect of sex and

SUBMITTER: Chan AYL 

PROVIDER: S-EPMC12515243 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature