Microbiological characterization of bacteremia in patients with chemotherapy-induced febrile neutropenia: systematic review and meta-analysis.

ABSTRACT:

Background

Febrile neutropenia (FN) is the most common and serious adverse event of chemotherapy for solid and hematological neoplasms, with infection as a major complication. FN occurs in 10%-50% of patients with solid tumors and over 80% with hematological malignancies, with mortality rates up to 11%.

Objective

To characterize bloodstream pathogens in post-chemotherapy FN through a systematic review and meta-analysis of studies published from 2013 to February 13, 2024.

Design

Systematic review and meta-analysis.

Data sources and methods

PubMed, Web of Science, Scopus, and Embase were searched using MeSH, Emtree, and keywords. Risk of bias was assessed using the JBI checklist. Random-effects proportions meta-analysis was performed.

Results

Twenty-two st

SUBMITTER: Correa AF 

PROVIDER: S-EPMC12515338 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature