Racial differences in aortic perivascular adipose tissue volume and its association with arterial stiffness in middle-aged men.

ABSTRACT:

Background and aims

Ectopic fat depots, such as aortic perivascular adipose tissue (aPVAT), are emerging as key factors in cardiovascular health. Individuals of African ancestry have lower ectopic fat levels, including visceral adipose tissue (VAT), than European ancestry. However, racial differences in aPVAT volume and its association with arterial stiffness remain unclear.

Methods

This cross-sectional study examined 325 men aged 40-49 (252 White, 73 African American). aPVAT and VAT were quantified using electron-beam computed tomography, and carotid-femoral pulse wave velocity (cfPWV), the gold standard measure of arterial stiffness, was assessed using a noninvasive testing device. Participant characteristics, aPVAT, and cfPWV were compared by race. Multivariable linear re

SUBMITTER: Sekikawa A 

PROVIDER: S-EPMC12515368 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature