The Interrelationship between Preconception Folate Nutritional Intake and Child Genetic Liability in the Risk of Childhood Acute Lymphoblastic Leukemia.

ABSTRACT:

Background

Prenatal maternal folate intake is associated with a reduced risk of childhood acute lymphoblastic leukemia (ALL), but how this interacts with children's genetic predisposition to folate deficiency remains unclear.

Methods

We used Mendelian randomization to investigate the causal link among serum folate, total homocysteine, and B vitamins on ALL using independent genetic instruments. These were evaluated in two independent childhood ALL genome-wide association studies: the California Childhood Cancer Record Linkage Project and the California Childhood Leukemia Study, the latter with available self-reported periconceptional nutrition data. Logistic regressions assessed the interrelationship between maternal nutrition and children's folate metabolism-related polygen

SUBMITTER: Xiang Y 

PROVIDER: S-EPMC12515492 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature