Immune-molecular nexus in reproductive disorders: mechanisms linking POI and RSA.

ABSTRACT:

Background

Infertility remains a prevalent global health concern, with Premature Ovarian Insufficiency (POI) and Recurrent Spontaneous Abortion (RSA) being common causes of female infertility.

Objective

This study aims to identify new central genes and potential therapeutic drugs for RSA and POI by integrating multi transcriptome data and machine learning algorithms.

Methods

This study utilized RNA sequencing data from patients with POI and RSA to identify key hub genes associated with these diseases. The analysis involved machine learning algorithms, mcode and Cytoscape, revealing important hub genes. The comprehensive evaluation includes functional annotation, protein-protein interaction (PPI) network, transcription factor (TF) gene regulatory network, microRNA (miR

SUBMITTER: Chen C 

PROVIDER: S-EPMC12515496 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature