Blood Pressure Mediates the Association Between Visceral-to-Subcutaneous Fat Ratio and Arterial Stiffness in Patients With Type 2 Diabetes.

ABSTRACT:

Background

Emerging evidence links visceral adiposity to arterial stiffness. However, the pathways underlying the association between an elevated visceral-to-subcutaneous fat ratio (V/S ratio) and brachial-ankle pulse wave velocity (baPWV), especially the mediating role of blood pressure, remain unclear in patients with diabetes. We aimed to assess the mediating effects of systolic blood pressure (SBP) and diastolic blood pressure (DBP) on the relationship between the V/S ratio and arterial stiffness in individuals with Type 2 diabetes mellitus (T2DM).

Methods

In this cross-sectional study, 1086 adults with T2DM were enrolled between 2022 and 2024. The visceral fat area (VFA) and subcutaneous fat area (SFA) were assessed using a dual bioelectrical impedance analyzer, and the

SUBMITTER: Tang D 

PROVIDER: S-EPMC12515565 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature