Effect of chronic benzodiazepine and benzodiazepine receptor agonist use on sleep architecture and brain oscillations in older adults with chronic insomnia.

ABSTRACT:

Study objectives

Insomnia in older adults is associated with widespread benzodiazepine (BZD) and benzodiazepine receptor agonist (BZRA) use despite evidence that chronic use disrupts sleep regulation and cognition. Little is known about BZD/BZRA effects on Non-rapid eye movement (NREM) slow oscillations (SO), spindles and their coupling, which is crucial for memory in older adults. Our objective was to investigate the effects of chronic BZD/BZRA use on sleep macro-architecture, electroencephalogram (EEG) relative power, SO and spindle characteristics and coupling.

Methods

After habituation polysomnography, second-night data were analyzed from 101 participants (66.05 ± 5.84 years, range: 55-80 years, 73 per cent female) were categorized into three groups: good sleepers (GS, n

SUBMITTER: Barbaux L 

PROVIDER: S-EPMC12515599 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature