Intermittent enteral nutrition may increase gastrointestinal complications and mortality in critically ill patients.

ABSTRACT:

Background

Enteral nutrition (EN) is a cornerstone of nutritional support in critically ill patients. The optimal EN delivery strategy for critically ill patients remains controversial, with conflicting evidence regarding potential impacts on complications and clinical outcomes.

Objectives

This meta-analysis aimed to compare the effects of intermittent enteral nutrition (IEN) versus continuous enteral nutrition (CEN) in critically ill patients.

Methods

A comprehensive search of PubMed, Embase, Scopus, and the Cochrane Library was performed from inception to June 25, 2025. Randomized controlled trials (RCTs) comparing IEN and CEN in critically ill patients were included. Primary outcomes included gastrointestinal complications (diarrhea, abdominal distension, vomiting,

SUBMITTER: Hu P 

PROVIDER: S-EPMC12515623 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature