Transcriptome analyses identify 10 deregulated hub genes and essential molecular mechanisms in early-onset colorectal cancer.

ABSTRACT:

Introduction

The rapid increase in early-onset colorectal cancer (EoCRC) case numbers in recent years indicated an urgent need to identify the essential mechanisms and markers for EoCRC diagnosis and treatment. Therefore, this study aimed to analyze the metadata to overcome the limitation of the sample number of previous EoCRC research and to identify central mechanisms and genes that are crucial for EoCRC.

Methods

This study employed statistical analysis of data from the cBioPortal and GEPIA databases to identify overexpressed EoCRC genes. Using a protein-protein interaction map, it identified hub genes. The function of these genes was clarified via risk model, survival, and cell model analysis.

Results and discussion

The results of clinical data analysis showed an i

SUBMITTER: Nguyen HD 

PROVIDER: S-EPMC12515628 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature