How to enhance prediction of clinical outcomes in poor responders: integrating high-specific assays for anti-mullerian hormone with antral follicle count.

ABSTRACT:

Introduction

Anti-Müllerian Hormone (AMH) and antral follicle count (AFC) are commonly used markers of ovarian reserve, yet their predictive accuracy in patients with low ovarian reserve remains limited. This study aimed to evaluate whether high-specific AMH assays targeting distinct molecular isoforms enhance the prediction of oocyte yield following ovarian stimulation (OS).

Methods

A prospective observational study was conducted from February 2019 to December 2021 in a tertiary fertility center, including 72 women with low ovarian reserve (AMH <1.1ng/mL). On cycle day 2/3 before OS, Antral Follicle Count (AFC) and serum FSH, LH, estradiol, progesterone, and AMH levels were measured with the Elecsys assay (Roche). Frozen serum samples were analyzed with four high-specific A

SUBMITTER: Melado L 

PROVIDER: S-EPMC12515637 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature