Resveratrol suppresses OSCC invasion and migration by regulating macrophage polarization via Syk signaling pathway.

ABSTRACT:

Introduction

An increasing amount of evidence indicates that the metastasis in oral squamous cell carcinoma (OSCC) is closely associated with the polarization phenotype of tumor-associated macrophages (TAMs). Resveratrol (RES) has been demonstrated to exert an inhibitory effect on the invasion and migration of OSCC cells. However, the mechanism by which RES inhibits OSCC invasion and migration remains to be fully elucidated.

Methods

RES for reprogramming TAMs (R-RES group) and RES group were used to interfere with the polarization of tumor-associated macrophages (TAMs). RT-qPCR, ELISA, Western blotting, immunofluorescence staining, transwell and wound-healing assays were used to investigate the anti-tumor mechanism of RES.

Results

R-RES reprogramed TAMs from M2 to M1

SUBMITTER: Li W 

PROVIDER: S-EPMC12515654 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature