Dietary and circulating butyrate are independently associated with kidney function in diabetes: a dual-cohort analysis.

ABSTRACT:

Background

The gut microbiota-derived metabolite butyrate has been implicated in maintaining renal homeostasis through anti-inflammatory and immunomodulatory pathways. However, evidence from large-scale human studies, especially in high-risk diabetic populations, remains limited. This study aimed to investigate the association between butyrate exposure and renal function in adults with diabetes, using a dual-cohort design.

Methods

We analyzed data from 7,723 adults with diabetes across ten NHANES cycles (1999-2018) to evaluate the association of dietary butyrate intake with estimated glomerular filtration rate (eGFR) and albuminuria. Multivariable linear regression, restricted cubic spline modeling, and subgroup analyses were performed with survey weighting. For external val

SUBMITTER: Zhao L 

PROVIDER: S-EPMC12515660 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature