Novel Insights Into the Genetic Basis Between Cholelithiasis and Four Dietary Patterns.

ABSTRACT: Previous epidemiological evidence has demonstrated that cheese, dried fruit, oily fish, and raw vegetables intake is inversely associated with the risk of cholelithiasis. Nevertheless, the underlying genetic mechanisms responsible for this relationship remain elusive, warranting a genomic-level investigation into the molecular pathways mediating these associations. To investigate potential genetic linkages, genome-wide association study (GWAS) datasets pertaining to cholelithiasis and four specific dietary patterns (cheese, dried fruit intake, oily fish, and raw vegetables) were employed within a multi-stage analytical framework. Initially, genome-wide genetic correlations were assessed through a combination of linkage disequilibrium score regression, genetic covariance analysis, and high-

SUBMITTER: Zheng E 

PROVIDER: S-EPMC12515698 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature