Diagnostic Performance of Magnifying Endoscopy With Crystal Violet Staining for Superficial Non-ampullary Duodenal Epithelial Tumors: A Single-center Prospective Study.

ABSTRACT:

Objectives

We previously reported a potential diagnostic algorithm for superficial non-ampullary duodenal epithelial tumors (SNADETs) using white-light magnifying endoscopy with crystal violet staining (ME-CV). This study aimed to determine the diagnostic performance of the scheme and compare it with the conventional white-light endoscopy (WLE) scoring system in a prospectively accumulated cohort.

Methods

This was a single-center prospective cohort study conducted over a 3-year period. The primary endpoint was the diagnostic performance of ME-CV in distinguishing Vienna classification (VCL) category 4/5 (C4/5) from category 3 (C3) SNADETs, including the positive predictive value (PPV) and negative predictive value (NPV), as evaluated by two expert endoscopists. We compared t

SUBMITTER: Kumei T 

PROVIDER: S-EPMC12515707 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature