Impact of onset age of type 2 diabetes mellitus on risk of renal complications compared to age-matched non-diabetic patients: Two cohort studies in the United Kingdom and Hong Kong.

ABSTRACT:

Objective

With the increasing incidence of early-onset type 2 diabetes mellitus (T2DM) and the significant burden of renal complications in younger patients, this study aimed to investigate the association between the age at onset of T2DM and the risks of renal complications.

Methods

Two retrospective cohort studies were conducted among adults without chronic kidney disease (CKD) from 2008 to 2013, utilising electronic health records from the United Kingdom (UK) and Hong Kong (HK). A total of 124 610 and 183 114 patients newly diagnosed with T2DM were included in the T2DM group, and 4 968 819 and 3 290 862 individuals without diabetes were included in the comparison group for the UK and HK cohorts, respectively. Participants were categorised into six age groups at baseline (

SUBMITTER: Wang B 

PROVIDER: S-EPMC12515758 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature