High-intensity statin therapy is associated with reduced coronary inflammation on CT in patients with type 2 diabetes mellitus.

ABSTRACT:

Aims

Pericoronary adipose tissue (PCAT) attenuation, assessed by coronary computed tomography angiography (CCTA), is a biomarker of coronary inflammation. Mean PCAT attenuation ≥ -70.5 Hounsfield Units (HU) corresponds to elevated inflammation and a higher future risk of myocardial infarction. While statins are known to possess anti-inflammatory properties, the impact of statin intensity on vascular inflammation remains underexplored in patients with type 2 diabetes mellitus (T2DM) and coronary atherosclerosis. We aim to evaluate whether high-intensity statins are associated with lower PCAT attenuation in this high-risk cohort.

Materials and methods

We retrospectively analysed 203 CCTAs performed at our institution between 1/1/2019 and 9/1/2024 in patients with T2DM who met

SUBMITTER: Wu B 

PROVIDER: S-EPMC12515762 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature