Glycaemic responses to metformin monotherapy by SNP clusters in patients with type 2 diabetes.

ABSTRACT:

Aims

This study retrospectively investigates the association between polygenic risk scores (PRS) derived from SNP clusters and glycaemic response to metformin in patients with newly diagnosed T2D.

Materials and methods

Utilizing a dataset from the Taiwan Precision Medicine Initiative, we evaluated alterations in fasting glucose (FBG) and glycated haemoglobin (HbA1c) in individuals newly diagnosed with T2D who underwent metformin monotherapy for a duration of 6 months. Glycaemic responses between those in the bottom 20% of PRS (Q1) and the top 20% of PRS (Q5) for each of the SNP clusters and for the combination of two clusters were analysed.

Results

In responses to metformin monotherapy, significant differences of FBG levels were detected in Q1 as compared to Q5 in ind

SUBMITTER: Sheu WH 

PROVIDER: S-EPMC12515771 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature