Metabolomic risk predictors of diabetic foot complications: A longitudinal observational study in type 1 diabetes.

ABSTRACT:

Aims

Diabetic foot complications are a growing challenge for both individuals and society, underscoring the need for medical treatments and reliable risk markers. This study aimed to identify circulating metabolites associated with the prevalence and incidence of diabetic foot complications in individuals with type 1 diabetes (T1D).

Materials and methods

A non-targeted panel of 75 serum metabolites was measured via mass spectrometry in 637 individuals with T1D from the Steno Diabetes Center Copenhagen, with a median follow-up of 10 years. Associations with diabetic foot complications (foot ulcers and lower extremity amputations) were assessed using linear regression for prevalent and Cox models for incident outcomes. Metabolites with significant crude associations (after mul

SUBMITTER: Andersen JA 

PROVIDER: S-EPMC12515773 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature