Similarities and differences in the intestinal actions of metformin and imeglimin.

ABSTRACT:

Aims

Imeglimin is a novel antidiabetic drug that shares structural similarity with metformin. While the intestinal effects of metformin have attracted widespread attention, those of imeglimin remain underexplored.

Materials and methods

C57BL/6J mice were treated with metformin or imeglimin for RNA sequencing of intestinal tissue. Gut microbiota composition was evaluated in KK-A^y mice by 16S rRNA sequencing of faecal samples. To assess direct effects on the human microbiome, a gut simulator was used with faecal samples from healthy and diabetic individuals. Intestinal glucose dynamics were assessed in C57BL/6J mice following administration of [¹⁸F]fluorodeoxyglucose, with subsequent analysis of tissue distribution.

Results

Bulk RNA-sequencing of c

SUBMITTER: Sugawara K 

PROVIDER: S-EPMC12515779 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature