Acidosis is associated with lower insulin sensitivity and incident type 2 diabetes in indigenous Americans: A prospective cohort study.

ABSTRACT:

Aim

Whether markers of acid accumulation [decreased plasma bicarbonate, increased anion gap (AG) and corrected anion gap (CAG)] are associated with insulin sensitivity and alter diabetes risk is unclear. We aimed to examine the association of these markers with the gold-standard measure of insulin sensitivity and incident type 2 diabetes.

Materials and methods

Healthy adults without diabetes enrolled in a longitudinal study had baseline measures of acidosis (bicarbonate, AG, CAG), insulin sensitivity by hyperinsulinaemic-euglycaemic clamp, and body composition. In cross-sectional analysis (n = 296, 188 male), the relationship between acid markers and insulin sensitivity (M-low) was evaluated. Progression to type 2 diabetes was evaluated by Cox regression models (per 1-SD cha

SUBMITTER: Trevino-Alvarez AM 

PROVIDER: S-EPMC12515791 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature