Delamanid-containing regimens over 24 weeks for the treatment of multidrug-resistant/rifampicin-resistant tuberculosis: preliminary results from a single center in a multicenter, prospective, observational study.

ABSTRACT:

Background

Single center preliminary results from a multicenter, prospective, observational study whose aims were to investigate the efficacy and safety of 24-week delamanid-containing regimens in Chinese multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) patients.

Methods

The study included adult patients (≤65 years old) with laboratory-confirmed MDR/RR-TB who were assigned to receive 24 weeks of delamanid (100 mg, twice daily) plus an optimized background regimen (OBR), followed by 5 ~ 12 months of continuation treatment with OBR alone according to World Health Organization and Chinese guidelines.

Results

Thirty-three patients were enrolled, 26 of whom completed the entire treatment course (intensive + continuation phases), with a treatment success ra

SUBMITTER: Yang F 

PROVIDER: S-EPMC12515798 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature