The functional <i>Mi-2/Foxo</i> complex targets <i>PGRP-SC2</i> for the <i>Drosophila</i> immune defense against bacterial infection.

ABSTRACT: Innate immunity is orchestrated by an array of conserved signaling pathways and transcriptional regulators. While Forkhead box O (Foxo) has emerged as a pivotal transcription factor in regulating immune homeostasis, its interaction with chromatin remodeling machinery remains poorly defined. Here, we identify the chromatin remodeler Mi-2 as a crucial component of the Drosophila antibacterial immune defense. Silencing of Mi-2 abrogates the induction of antimicrobial peptides in adult flies and leads to reduced host survival following systemic bacterial challenge. Co-immunoprecipitation assays demonstrate a physical interaction between endogenous Mi-2 and Foxo in the Drosophila fat body. Of interest, Foxo silencing phenocopies Mi-2 knockdown, suggesting a fu

SUBMITTER: Zheng X 

PROVIDER: S-EPMC12515809 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature