<i>Neoshirakia japonica</i> (Siebold & Zucc.) Esser [Euphorbiaceae] fruit suppresses obesity and obesity-induced inflammation in adipocytes, macrophages, and obese mice.

ABSTRACT:

Introduction

The objective of this study was to demonstrate the anti-obesity and anti-inflammatory effects of Neoshirakia japonica (Siebold & Zucc.) Esser [Euphorbiaceae] under obesity-induced conditions. Traditionally used in ethnopharmacology to dispel "wind-dampness" and "damp-heat," these effects can be interpreted in modern medicine as chronic inflammation and metabolic imbalance associated with obesity.

Methods

The anti-obesity and anti-inflammatory potential of N. japonica fruit extract (NJFE) was evaluated in high-fat diet (HFD)-induced obese mice, 3T3-L1 adipocytes, and LPS-stimulated RAW264.7 macrophages. Mitochondrial function was assessed using MitoTracker fluorescence, and LC-MS analysis was performed to identify the chemical fingerprint and putati

SUBMITTER: Lee E 

PROVIDER: S-EPMC12515811 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature