Serum small RNA profiling identifies prognostic biomarkers for sepsis mortality prediction.

ABSTRACT:

Background

Sepsis remains a leading cause of mortality in critically ill patients, with current prognostic tools showing limited accuracy for outcome prediction. While traditional clinical parameters and inflammatory biomarkers provide some prognostic information, there is an urgent need for novel molecular biomarkers that can accurately predict sepsis outcomes to guide clinical decision-making and therapeutic interventions. Circulating small RNAs, including tRNA-derived small RNAs (tsRNAs) and microRNAs (miRNAs), have emerged as potential biomarkers due to their stability in circulation and regulatory roles in immune responses and inflammatory processes.

Methods

This study enrolled 26 sepsis patients admitted to the intensive care unit, who were stratified into recovery (

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12515841 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature