Immediate versus staged complete revascularization in patients with acute coronary syndrome and multivessel disease: a meta-analysis of randomized controlled trials.

ABSTRACT:

Background

A series of trials have confirmed that complete revascularization is more beneficial for patients with acute coronary syndrome (ACS) and multivessel disease than culprit-only revascularization. However, the optimal timing of complete revascularization remains controversial. It is unclear whether immediate complete revascularization is safer and more effective than staged complete revascularization.

Method

This meta-analysis of randomized controlled trials aimed to compare the efficacy and safety of immediate vs. staged revascularization in patients with ACS. The primary outcome was major adverse cardiovascular events (MACE), which were defined as a composite endpoint. Risk ratios (RRs) were calculated using the Mantel-Haenszel (M-H) fixed-effect model. Trial seque

SUBMITTER: He L 

PROVIDER: S-EPMC12515846 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature