Identification of novel genetic biomarkers for ChAdOx1 nCoV-19 mediated immunogenicity.

ABSTRACT:

Background

Research comprehensively examining factors for COVID-19 DNA vaccine responses is lacking, particularly in Asian populations. This study aims to investigate biomarkers of reactogenic and immunogenic responses after DNA-based COVID-19 vaccination in a Taiwanese population.

Methods

A genome-wide association study (GWAS) of 415 Taiwanese healthcare workers was conducted to identify genetic variants associated with reactogenic and immunogenic responses to the first and second doses of ChAdOx1 nCoV-19 vaccine. Furthermore, gene set enrichment analysis was conducted to elucidate the underlying biological pathways. Finally, a polygenic score (PGS) was utilized to assess the synergistic host effects on neutralizing antibody (NT50).

Results

We identified 501 suggesti

SUBMITTER: Chou WH 

PROVIDER: S-EPMC12515888 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature