FcγRIIIA -activating antibodies in dengue virus infection reveals a distinct transient cross-reactive profile.

ABSTRACT: Dengue viruses belong to the genus Flavivirus and consist of a serocomplex of four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4). As arthropod-borne viruses (arboviruses), their transmission is mediated primarily by the vector Aedes aegypti. Antiviral immune response is one of the most crucial factors influencing the progression from uncomplicated to severe dengue virus (DENV) infection. Two types of antibody responses are elicited during a DENV infection: one specific to the infecting serotype (serotype-specific or homotypic response) and another that cross-reacts with other serotypes (cross-reactive or heterotypic response). Both responses play roles in the protection against and in the induction of immunopathogenesis of DENV disease. In the case of the humoral immune response, the bala

SUBMITTER: Soto-Garita C 

PROVIDER: S-EPMC12515889 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature