Digital localization of intraoperative samples enhances margin analysis precision in oral squamous cell carcinoma.

ABSTRACT:

Objectives

The intraoperative margin assessment technique enhances local control of Oral Squamous Cell Carcinoma (OSCC). However, the standard frozen section analysis (FSA) procedure does not allow precise interpretation of the final histopathological results. For this reason, we have developed a modified intraoperative margins (IM) assessment protocol using virtual 3D images of resected OSCC.

Material and methods

The pilot study included 10 patients with OSCC located in the floor of the mouth (FOM, n = 3), tongue (TC, n = 2), maxilla (MT, n = 1), and retromolar triangle (RMT, n = 4). After excision, OSCCs were scanned and mapped, marked on the virtual preparation of the IM collection sites. The modified pathological assessment of the IM enabled t

SUBMITTER: Michcik A 

PROVIDER: S-EPMC12515900 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature