Protective effects and mechanism of resveratrol in animal models of pulmonary fibrosis: a preclinical systematic review and meta-analysis.

ABSTRACT:

Background

Pulmonary fibrosis (PF) is a chronic lung disease characterized by ongoing interstitial scarring. Current treatments can only slow the progression of the disease. Resveratrol (RES), a natural polyphenolic compound, has become a potential therapy for PF because of its multiple biological effects, including anti-fibrotic, anti-inflammatory, and antioxidant properties.

Objectives

To clarify RES's efficacy, safety, and mechanism of action in treating PF through a preclinical systematic review.

Methods

A computerized search of eight databases (up to 6 March 2025) was conducted to identify in vivo animal experiments on RES treatment for PF. The SYRCLE tool was used to assess the risk of bias, and meta-analysis was performed using RevMan 5.4 and Stata 17.0.

SUBMITTER: Yin Y 

PROVIDER: S-EPMC12515909 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature