Arrhythmic events pertinent with antidepressants: a Bayesian disproportional analysis mining the FDA Adverse Event Reporting System database.

ABSTRACT:

Objective

The aim of this study was to investigate pharmacovigilance (PV) and make pairwise comparisons on arrhythmic events among antidepressants from the US Food and Drug Administration Adverse Event Reporting System (FAERS).

Methods

Records regarding antidepressants treating depression and major depression from the first quarter of 2015 to the third quarter of 2023 documented in the FAERS database were harvested. The primary endpoint of this study was PV for arrhythmic events, including QT prolongation/Torsades de Pointes (TdP), atrial fibrillation (AF), heart block, and ventricular arrhythmia. The secondary endpoints comprised the pairwise comparisons on constituent ratio and severity of outcomes of drugs of interest on the above four diseases.

Result

Ultimately,

SUBMITTER: Cao S 

PROVIDER: S-EPMC12515912 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature