<i>Centella asiatica</i> enhances diabetic wound healing by decreasing macrophage-driven inflammation <i>via</i> the AKT/MAPK/NF-κB pathway.

ABSTRACT:

Background

Diabetic foot ulcers (DFU) pose a major global healthcare challenge, necessitating novel therapeutic strategies. Although Centella asiatica has demonstrated pharmacological potential, its role in diabetic wound healing remains unclear. This study aims to investigate the mechanisms through which Centella asiatica promotes wound healing under diabetic conditions.

Methods

A systematic pharmacological approach was employed to identify potential targets of Centella asiatica in DFU. In vitro experiments used Raw264.7 macrophages stimulated by advanced glycation end products (AGEs). For in vivo validation, a diabetic mouse model was established using high-fat diet and streptozotocin (STZ). Full-thickness skin wounds were topically treat

SUBMITTER: Xiao F 

PROVIDER: S-EPMC12515935 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature