Loss of 5-HT_2C receptor function alters motor behavior in male and female mice with and without spinal cord injury.

ABSTRACT: The 5-HT_2C receptor is involved in the regulation of spinal motor function, specifically in both volitional and involuntary motor behavior. It contributes to various aspects of voluntary movement, such as locomotion, gait, coordination, and muscle contractions. It also contributes to involuntary motor behavior (i.e., spasms), which affects many individuals with spinal cord injury. Despite its known involvement in motor function, additional research in uninjured mice is required to assess whether specific gait parameters and muscle contractility are directly linked to the 5-HT_2C receptor. In injured mice, further research is needed to determine whether the expression of the 5-HT_2C receptor is altered in the lumbar and sacral spinal cord after injury. It is a

SUBMITTER: Sim MI 

PROVIDER: S-EPMC12515959 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature