Prognostic implications of right ventricular to pulmonary artery uncoupling in cardiac amyloidosis.

ABSTRACT:

Background

Right ventricular-pulmonary arterial (RV-PA) uncoupling in cardiac amyloidosis (CA) has been underexplored, with focus mainly on tricuspid annular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (PASP). This study aims to evaluate the association of various echocardiographic surrogates of RV-PA coupling with outcomes in cardiac transthyretin (ATTR-CA) and light-chain (AL-CA) amyloidosis.

Methods

We analyzed RV-PA coupling in patients diagnosed with ATTR-CA and AL-CA at our center between 2014 and 2023. RV-PA coupling was assessed using TAPSE/PASP, fractional area change (FAC)/PASP, and RV free wall strain (RVFWS)/PASP. The primary endpoint was all-cause mortality.

Results

A total of 120 patients (86% ATTR-CA, 14% AL-CA) were included in

SUBMITTER: Jakstaite AM 

PROVIDER: S-EPMC12515962 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature