IL-17⁺/IL-10⁺ Ratio in TCRαβ⁺ CD4^- CD8^- T Cells As a Marker of Disease Activity in Lupus-Prone Mice and Patients With Systemic Lupus Erythematosus.

ABSTRACT:

Objective

T cell receptor αβ⁺ (TCRαβ⁺) CD4^- CD8^- double-negative (DN) T cells are expanded in lupus-prone mice and patients with systemic lupus erythematosus (SLE), produce interleukin-17 (IL-17), and contribute to disease pathogenesis. However, it is not known whether there is functional heterogeneity within this population. This study aimed to determine whether a subset of DN T cells produces IL-10 and whether the ratio of IL-17⁺/IL-10⁺ DN T cells correlates with disease activity.

Methods

Flow cytometry was used to analyze DN T cells in lupus-prone MRL/lpr mice and patients with SLE. IL-17⁺ and IL-10⁺ DN T cells were identified and quantified in the peripheral blood and lymphoid organs.

SUBMITTER: Imai R 

PROVIDER: S-EPMC12516011 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature