Coordinated Transcriptomic and Epigenetic Approach Reveals Molecular Features Underlying Natural Mating Ability in Captive Male Giant Pandas.

ABSTRACT: Natural mating ability is a critical behavioral trait for the reproductive success of captive endangered mammals, and its loss often reflects declining adaptability and potential physiological dysfunctions. However, the underlying molecular regulatory mechanisms remain poorly understood. In this study, we integrated blood transcriptome and whole-genome DNA methylation (whole-genome bisulfite sequencing) data to systematically explore the molecular basis of natural mating ability differences in captive male giant pandas (Ailuropoda melanoleuca). A total of 21 male individuals, which were classified into either capable (with successful natural mating experience) or incapable (with repeated mating failure despite physical health) groups, were sampled from three breeding centers. RNA-se

SUBMITTER: Yan Z 

PROVIDER: S-EPMC12516017 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature