Prospective validation of a pretreatment 18F-FDG PET/CT and mean lung dose model for early radiation pneumonitis.

ABSTRACT:

Background and purpose

Early onset radiation pneumonitis (RP_Early) after concurrent chemoradiotherapy (cCRT) can lead to consolidation immunotherapy (IO) discontinuation, and poor survival in locally advanced non-small cell lung cancer (LA-NSCLC). This work assessed the external validity of a previously published RP_Early risk model.

Material and methods

The RP_Early risk model utilizes pretreatment 18F-FDG PET/CT imaging of the normal lungs and the mean lung dose (MLD). The 90th percentile of the standardized uptake value (SUV_P90) and the MLD model parameters from the previous derivation cohort (N = 160) were applied in the independent cohort (50 consecutive LA-NSCLC patients treated with cCRT and IO) where model performance was eva

SUBMITTER: Thor M 

PROVIDER: S-EPMC12516051 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature