Safety of Prefrontal Cortex Biopsies During Deep Brain Stimulation Procedures.

ABSTRACT:

Background and objectives

A goal of medical research is to advance knowledge of the molecular biology underlying human brain function. Yet, few studies of human brain biology have been performed using brain tissue from living people. This is due to the lack of safe approaches to sampling the living human brain for rigorous scientific inquiry. The Living Brain Project (LBP) developed a method to biopsy a small volume of prefrontal cortex (PFC) tissue during deep brain stimulation (DBS) lead placement procedures. The objective of this LBP report was to establish the safety of the PFC biopsy approach.

Methods

Acute adverse events (ie, infection, intracranial hemorrhage [ICH], and seizures) were tracked after 1152 DBS procedures performed on 590 patients. A PFC biopsy was obtain

SUBMITTER: Akkus S 

PROVIDER: S-EPMC12516147 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature