Global, Regional, and National Burdens of Parkinson's Disease in Adults Aged 20-50 Years, 1990-2021: A Cross-Sectional Study.

ABSTRACT:

Background and aims

Early-onset Parkinson's disease (EOPD), characterized by symptom manifestation between the ages of 20 and 50 years, imposes substantial clinical, psychosocial, and economic burdens. We evaluated the global, regional, and national burdens of EOPD from 1990 to 2021, emphasizing trends in incidence, prevalence, mortality, and disability-adjusted life years (DALYs) and projected future trajectories to 2050.

Methods

Using age-standardized rates (ASRs) and absolute numbers from the Global Burden of Disease 2021 study across 204 countries, this analysis covers incidence, prevalence, deaths, and DALYs from 1990 to 2021. we analyzed temporal trends via Joinpoint regression. A decomposition analysis was used to quantify the contributions of aging, population growth

SUBMITTER: Shen L 

PROVIDER: S-EPMC12516154 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature