Reduced Growth and Inflammation in Lrp5^-/- Mice Adipose Tissue.

ABSTRACT: Obesity is a major cause of chronic disease morbidity-mortality. Understanding the mechanisms triggering its promotion will allow the development of effective treatments. Cardiovascular diseases are associated with high-fat diet ingestion; however, how adiposity is distributed in relation to fat intake is not known. The lipoprotein receptor LRP5 participates in lipid handling in several cells. Whether LRP5 and its effector canonical WNT signalling pathway are involved in high-fat diet-induced adipose tissue distribution remains unknown. We fed Wt and Lrp5^-/- mice with a high cholesterol diet and analysed adipose and inflammatory markers. More fat deposition in Wt mice than in Lrp5^-/- mice is observed upon high-fat diet intake. Lipoprotein receptor expression is increa

SUBMITTER: Luquero A 

PROVIDER: S-EPMC12516158 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature