Accelerated biological aging is associated with cognitive performance among older adults in Mexico, India, United States, and England: A cross-national analysis.

ABSTRACT:

Introduction

Biological age (BA) measures were developed to capture changes in aging that chronological age does not. We aimed to investigate the association between BA and cognitive performance and whether the Klotho protein mediated this association.

Methods

We used data from participants aged 60 years or older from Mexico, India, the United States, and England. We used linear regression to investigate the association between BA and cognitive performance. Mediation analysis using data from the United States used the counterfactual framework.

Results

In 8547 participants, 53.6% were women, mean (SD) chronological age was 69.6 (7.6) years and mean (SD) biological age 70.2 (9.6) years. Higher biological age was associated with poorer cognitive performance across all ev

SUBMITTER: Martins-Pais IMN 

PROVIDER: S-EPMC12516237 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature