Chronic cerebral hypoperfusion-induced myelin loss in normal-appearing white matter correlates with cognitive decline: insights from moyamoya disease.

ABSTRACT:

Introduction

Chronic cerebral hypoperfusion (CCH)-induced white matter hyperintensities (WMHs) are a well-established risk factor for cognitive impairment and dementia. While animal and post mortem studies suggest that myelin loss in normal-appearing white matter (NAWM) precedes WMHs, in vivo evidence in human brain remains limited. We aimed to investigate the associations between myelin changes in NAWM, CCH, and cognitive function in patients with moyamoya disease (MMD, a human model of CCH).

Methods

We included 58 patients with MMD and 36 healthy controls, and all participants underwent 3.0T magnetic resonance imaging (MRI) with T1-weighted, T2-weighted, and arterial spin labeling (ASL) sequences. Myelin was assessed by the T1-weighted/T2-weighted ratio (rT1/T2), an

SUBMITTER: Yu X 

PROVIDER: S-EPMC12516246 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature