Coronary Microvascular Dysfunction Related to Hydroxychloroquine-Induced Cardiomyopathy.

ABSTRACT:

Background

A 69-year-old woman with seropositive rheumatoid arthritis presented with subacute worsening of her chronic chest pain.

Case summary

Cardiac magnetic resonance demonstrated new diffuse edema, patchy late gadolinium enhancement, and a reduction in myocardial perfusion reserve index, which raised concern for an infiltrative cardiomyopathy leading to microvascular dysfunction. An endomyocardial biopsy resulted in a rare diagnosis of drug-induced cardiomyopathy.

Discussion

We report a new association between this drug toxicity and coronary microvascular disease. This represents not only a new finding but potential expanded understanding of the pathophysiology of this disease condition. This finding could have implications for both diagnostic testing and disease

SUBMITTER: Richards D 

PROVIDER: S-EPMC12516263 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature