Probabilistic mapping of the antiparkinsonian effects of pallidal deep brain stimulation.

ABSTRACT: Deep brain stimulation of the internal globus pallidus effectively treats motor symptoms and drug-induced fluctuations in advanced Parkinson's disease-but is complicated by a high variability in outcomes. In a minority of patients, even stimulation-induced aggravation of akinesia has been reported. Previous works and clinical practice suppose an antiparkinsonian sweetspot in a sensorimotor segment in ventrocaudal internal globus pallidus. However, the detailed functional anatomy of the nucleus is still a matter of debate. We examined 39 patients with Parkinson's disease undergoing pallidal deep brain stimulation from two centres. Deep brain stimulation outcomes were scaled using the percentage change in the motor part of Unified Parkinson's Disease Rating Scale in MED-OFF pre- and postoper

SUBMITTER: Navratil P 

PROVIDER: S-EPMC12516314 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature