Vascular anatomy of L1 vertebral body in Wistar rat-corrosion-fluorescence, diaphanization and histological analysis, comparison to humans, and importance in blood supply-related investigation.

ABSTRACT:

Background

The factors influencing bone healing in complete burst fractures-key to deciding between stabilization or vertebral replacement-remain poorly defined. Arterial vascularization and bone nutrition are known to affect healing or progression to necrosis. However, the role of vascular injury in vertebral fractures is not yet conclusively demonstrated and is not currently factored into the decision-making for ad initium vertebral body replacement surgery. This study aims to analyze the vascularization of the L1 vertebral body in Wistar rats and compare it to human anatomy. The goal is to evaluate the suitability of the Wistar rat as a model for studying vertebral blood supply.

Methods

Forty-three female Wistar rats (3 months old, 250-350 g) were used. After intraventric

SUBMITTER: Moura DL 

PROVIDER: S-EPMC12516398 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature