A workflow for correlative <i>in situ</i> nanochip liquid cell transmission electron microscopy and atom probe tomography enabled by cryogenic plasma focused ion beam.

ABSTRACT: Operando/in situ liquid cell transmission electron microscopy (LCTEM) allows for real time imaging of dynamic nanoscale liquid-based processes. However, due to the thick liquid cell of traditional LCTEM holders and thus scattering of the electron beam passing through the cell, the achievable spatial and chemical resolution is limited. Cryogenic atom probe tomography (cryo-APT) overcomes these limitations by offering (near-)atomic scale compositional analysis of frozen liquid-solid interfaces. However, APT provides limited structural analysis and has no capacity for dynamic or operando liquid cell studies. This work presents a novel workflow for site-specific cryo-APT sample preparation of liquid-solid interfaces from in situ electrochemical LCTEM micro-electro-m

SUBMITTER: Mulcahy N 

PROVIDER: S-EPMC12516483 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature